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To demonstrate significant postbronchodilator improvement in lung function, specifically in terms of FEV1 (Forced Expiratory Volume in one second), a minimum increase of 12% is widely accepted in clinical practice. This benchmark is used to assess the reversibility of airway obstruction in conditions like asthma and chronic obstructive pulmonary disease (COPD).

The rationale behind selecting 12% as the threshold lies in its balance between clinical significance and statistical reliability. An increase of this magnitude not only indicates a change that is unlikely due to measurement variability but also suggests a meaningful improvement in airway patency following bronchodilator administration. This can influence treatment decisions and management plans for the patient.

Lower percentages might not adequately reflect a clinically notable improvement, while higher thresholds may exclude patients who benefit from bronchodilator therapy. Thus, the 12% increase serves as an appropriate criterion in clinical assessments for evaluating postbronchodilator response.